Resolution of calcinosis using bisphosphonates in overlap syndrome – a case report

Abstract Introduction Calcinosis cutis is a common complication of pediatric rheumatologic diseases. However, there currently no consensus on first-line treatment. Bisphosphonates have been described as successful treatment in several case studies, but most these cases are limited to patients with isolated juvenile dermatomyositis or systemic sclerosis. Specifically, reports their usefulness treating overlap syndromes and mixed connective tissue disorders. Case presentation We describe the 13 year-old girl syndrome features lupus erythematosus. After 22 months extensive immunosuppressive therapy, including monthly IVIG Rituximab, she continued pain weakness lower extremities. A CT scan was performed which showed significant multifocal soft calcifications pelvis. She started oral alendronate goal improving her calcinosis symptoms. our patient reported subjective improvement extremity weakness, well complete resolution abnormalities previously seen physical examination. repeat pelvis after 11 therapy demonstrated calcinosis. Conclusions report bisphosphonates dermatomyositis-systemic erythematosus syndrome. These results provide further evidence that can be used successfully treat Additionally, new they specifically syndrome, has not reported.